What is the role of ACh at the neuromuscular junction? Describe the resulting electrical changes in the muscle.

1. Elizabeth suffers from severe muscle weakness. She finds it difficult to move her facial muscles, and the simplest facial movements involve a lot of effort. She was told she suffers from a disease characterized by a reduced effectiveness of released ACh and frequent failure of neuromuscular transmission.
a) What is the role of ACh at the neuromuscular junction? Describe the resulting electrical changes in the muscle.
b) Elizabeth’s doctors believe his disease is an autoimmune disorder because it targets acetylcholine receptors at the neuromuscular junction? What happens to the ACh if this is the case?
c) Propose a treatment option for Elizabeth and describe how and why you think this treatment would work- do not provide a description of existing drugs. Explain what a drug should do to help this condition.
d) What targets other than the receptor might be affected by an autoimmune disorder that might have similar effects?