1- After reading the article “Hemoglobin Variants: Biochemical Variants and Clinical Correlates,” by Thom, Dickson, Gell, and Weiss (2013), select and post two unique characterized hemoglobin variants with altered oxygen binding

2- Describe a unique example of a competitive inhibitor and how it functions

3- Discuss a specific disease that is caused by abnormal receptor tyrosine kinase signaling in a cell.

4- In some cases, patients are given steroid hormone replacement therapy or athletes may take exogenous steroid hormones to enhance performance. Discuss the potential cellular effects that can occur with high levels of steroid hormone administration and include your opinion on the appropriate use of steroid hormone replacement.

5- Go to the National Center for Biotechnology Information (NCBI) Gene website provided in the topic materials and search for “Human Integrin.” How many different integrin genes were in your search results? Select one of the integrin genes from your search results that has not been posted by a peer, and describe a disease or phenotype associated with that integrin.

6- Read the diseases and phenotypes originally reported by your peers and respond with the location that type of integrin may be expressed in the human body.

7- Describe a characterized mutation in a unique cell cycle gene, and the resulting human disease that can result from it.