How Cas9 detects and cleaves DNA targets, and cellular responses to the resultant double strand DNA break?
How Cas9 detects and cleaves DNA targets, and (eukaryotic) cellular responses to the resultant double strand DNA break?
How Cas9 detects and cleaves DNA targets, and (eukaryotic) cellular responses to the resultant double strand DNA break?
Diseases that affect the Reproductive system
This paper needs to be written on diseases that affect the reproductive system, it must state the cause and effect of the diseases as well as, what treatments is there for the disease if any, if not explain why there are no treatments. Also include at least one article as well as all sources and references on the sixth page. It should be written in APA format.
“For the drug you have chosen present a detailed overview of the research that underpins a molecular/biochemical and medical understanding of the medical condition(s) that it treats. Then discuss the discovery of the drug itself, critically evaluate the research that went into developing it as an effective treatment, how its efficacy in treating the medical condition is monitored, the clinical trials process that allowed its approval for use, and how it is now produced en masse for provision to the health sector”.
Instructions
Write a case study essay of 2000 words following the brief above.
Develop the case study in a critical manner and use examples to illustrate your answer where appropriate.
You should start with an introduction, have a well written and logical section of information and discussion in the main part and end with a conclusion which is substantiated by the discussions which preceded it.
The case study should be well referenced in an appropriate format . You must quote the references in full at the end of the essay to say where you obtained your information. Primary references will get more credit than quoting either text books or reviews. Please avoid quoting websites. For this assignment we would expect between 20 to 25 references.
The HER2/HER3 heterodimer is one of the main activators of the PI3K/AKT and Ras/MEK/ERK signaling pathways. Downstream of these pathways are key regulations that would upregulate mesenchymal transition and lead to metastasis of breast cancer. HER2 does not directly to bind to any ligand but dimerizes with HER3 as previously mentioned as HER3 lacks RTK activity on its own. In cancer, HER2 homodimerize with itself when there is a high concentration. HER2 can localize to the nucleus and initiate transcriptional activity. Nuclear HER2 also acts as a STAT3 transcriptional co-activator. This stimulates breast cancer cell growth.
What are some cancer therapeutic drugs/treatments/strategies that target HER2 and HER3? How do they disrupt signaling pathway?
Write a minimum of two paragraphs for each discussion.
What topic(s) did you like the most? What topic(s) was the most challenging? Why?
Describe how learning anatomy and physiology will help you in your career?
What are you looking forward to learning more about throughout your education and career?
Global Warming Research Paper
If your topic is relatively new, or something that is still being developed, you may want to include where the future is heading. Gene therapy isn’t commonly used now; why not? What needs to be perfected?
How will that be done?
You should discuss the good and bad side of your topic . What benefits have we gained from gene therapy? What are the downfalls of the smallpox vaccine? How can DNA profiling be used in positive and negative ways? Why did/are some people “all for” this topic? Why are some people dead set against it?
Global Warming Research Paper
If your topic is relatively new, or something that is still being developed, you may want to include where the future is heading. Gene therapy isn’t commonly used now; why not? What needs to be perfected?
How will that be done?
You should discuss the good and bad side of your topic. What benefits have we
gained from gene therapy? What are the downfalls of the smallpox vaccine? How can DNA profiling be used in positive and negative ways? Why did/are some people “all for” this topic? Why are some people dead set against it?
Summarize the reasons that you are applying for the SIMR Program, how your participation in the program fits into your future educational and career objectives, and why you feel you are a good candidate for the program. You may also discuss your institute/area of research preferences and personal goals.
SIMR Program
Summarize the reasons that you are applying for the SIMR Program, how your participation in the program fits into your future educational and career objectives, and why you feel you are a good candidate for the program. You may also discuss your institute/area of research preferences and personal goals.
Description
How are bacteria and yeast enhancing our abilities to understand the cytochrome enzymes?