Can anyone figure out some examples about TGF- in hematopoietic disease? and any therapeutic avenues?

In vitro, TGF-β is one of the most effective inhibitors of hematopoietic stem cell proliferation. TGF-β has been proposed to be a fundamental regulator of HSC quiescence, sustaining a slow-cycling state of HSCs in vivo, due to their inherently quiescent state. In vitro neutralization of TGF-β was demonstrated to wake up early hematopoietic progenitor cells, confirming this theory. Changes in cytokine receptor expression and up-regulation of cyclin-dependent kinase inhibitors such as p15, p21, and p27 have been hypothesized as molecular pathways for TGF-β mediated growth suppression.

Can anyone figure out some examples about TGF- in hematopoietic disease? and any therapeutic avenues?